This presentation provides a comprehensive overview of the evolution of Pressurised Metered Dose Inhalers (pMDIs) from their inception to the current focus on Low Global Warming Potential (GWP) propellants. It highlights the significant milestones in the journey of pMDIs, starting from the approval of the first pMDI, Medihaler Iso, to the current research on low GWP propellants. 

The presentation also discusses the key considerations for switching propellants, including propellant selection, container closure system material compatibility, formulation specificities, and dose selection. It provides valuable insights into the challenges and opportunities in the development of pMDIs with low GWP propellants. 

This presentation is a valuable resource for anyone interested in the development of pMDIs and the future of inhaler technology.