The pharmaceutical industry is witnessing a significant shift in the reformulation of injectable drug products for nasal delivery. This article presents a case study of using modelling to accelerate the reformulation process. The focus is on Nanopharm’s SmartTrack™, a process that combines breath profiles recording with realistic aerodynamic particle size distribution performance testing, in-vitro dissolution, and morphology directed particle sizing and chemical imaging of a representative lung dose and regional deposition modelling.