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This research article presents a comparative study on dry powder inhaler formulations of Fluticasone Propionate. The study aims to provide a comprehensive understanding of the different formulations and their effectiveness in delivering the drug. Fluticasone Propionate is a corticosteroid that is commonly used in inhalers for the treatment of asthma and chronic obstructive pulmonary disease (COPD). The research focuses on the various factors that influence the effectiveness of these inhalers, including the particle size of the drug, the design of the inhaler device, and the formulation of the dry powder. The results of the study provide valuable insights that can guide the development of more effective inhaler formulations in the future. The research also contributes to the broader understanding of drug delivery systems, particularly in the context of respiratory diseases.