We announced our strategic alliance with Sciarra Laboratories Inc. in July 2018. This has enabled both Nanopharm and Sciarra Labs to provide end-to-end services for the development of metered dose inhaler (MDI) formulations to our clients.
This one-stop shop offers the capability of handling solution and suspension MDI formulations. Our combined capabilities enable laboratory, pilot and commercial scale filling of MDIs from 20 – 500L volume. These facilities encompass two-stage filling, single stage filling and dual-shot filling.
Group combines 30,000 square feet of state-of-the-art R&D and GMP manufacturing facilities in the UK and US. Hicksville, NY, facility enables pilot scale GMP manufacture of MDIs using single stage filling system for pilot stage filling with 134a, 227 and new propellants. Carmel, NY, facility currently allows large scale commercial manufacture.
Our services for MDI development include:
- Container closure system selection
- Device selection
- API and excipient selection
- Suspension stability investigations
- Formulation optimisation
- Process development for single, two-stage and dual-filling
- Stability investigations