DISSOHALE encompasses a range of in vitro dissolution based techniques that have been specifically developed for both routine quality control testing and as a research and development tool for orally inhaled and nasal drug products.
Our DISSOHALE technologies can be used for testing batch-to-batch consistency and detection of possible manufacturing deviations of orally inhaled and nasal drug products. In an R&D setting, our focus is on biopharmaceutics and understanding the role of material properties, processing conditions on dissolution properties and as a tool to estimate dissolution behaviour in vivo.
DISSOHALE technologies have been successfully used to characterise both suspension and solution based pMDI and DPI formulations. Our range of approaches have significantly increased sensitivity of dissolution testing to possible changes in the physico-chemical properties of the APIs, formulated product and difference in the deagglomeration efficiency of inhaler devices.